MMJ Ingredient Prevents Brain Damage in Mice

May 31, 2013

The words “mar­i­juana” and “brain dam­age” usu­ally go in that order in med­ical lit­er­a­ture. An Israeli researchers has flipped them around, find­ing that THC, the active ingre­di­ent in mar­i­juana, may arrest some forms of brain dam­age in mice. The loco weed already is favored by those who suf­fer from chronic dis­eases, not to men­tion fans of Cypress Hill, Bob Mar­ley and the Grate­ful Dead. But phar­ma­col­o­gist Josef Sarne of Tel Aviv Uni­ver­sity found that a minus­cule amount of tetrahy­dro­cannabi­nol may pro­tect the brain after injuries from seizures, toxic drug expo­sure or a lack of oxy­gen. The amounts wouldn’t qual­ify as much more than a second-hand whiff of kine bud – the quan­tity of THC is an order of 1,000 to 10,000 lower than that in a whole spliff. The new dope on mar­i­juana was pub­lished in Behav­ioural Brain Research and Exper­i­men­tal Brain Research, which are pro­fes­sional jour­nals, not nick­names for Hemp­Con or Burn­ing Man. Other researchers didn’t tend to Bog­art the joint as much. They sug­gested using high — their word — doses within about half an hour after such injury. Sarne would spread a smaller dose over as much as a week. The chem­i­cal is thought to jump-start bio­chem­i­cal processes that pro­tect brain cells and pre­serve cog­ni­tive func­tion. Researchers injected mice with a low dose of THC either before or after expos­ing them to brain trauma. Fel­low rodents in a con­trol group got their brains bonked with­out the dose. About a month or two later, the mice that got the THC treat­ment per­formed bet­ter in behav­ioral tests mea­sur­ing learn­ing and mem­ory and showed they had greater amounts of neu­ro­pro­tec­tive chem­i­cals than the control-group mice. Oddly, it may be brain dam­age on a small scale that causes the brain to shift into pro­tec­tive mode. Researchers the­o­rize the THC causes minute dam­age to the brain that helps build resis­tance and trig­gers pro­tec­tive mea­sures in the face of more severe injury. The low dose and long win­dow for admin­is­ter­ing it would have obvi­ous ben­e­fits after an injury, but it also could mean that THC can be given prior to a pro­ce­dure that may carry risk of brain injury, includ­ing inter­rup­tion of blood flow to the brain dur­ing surgery. Sarne believes it also could be safe for reg­u­lar use among epilep­tics. Source: Los Ange­les Times (CA) Author: Geof­frey Mohan Pub­lished: May 31, 2013 Copy­right: 2013 Los Ange­les Times Con­tact: letters@​latimes.​com Web­site: http://​www​.latimes​.com/

82cd459e58smouse.jpg 150x87 MMJ Ingredient Prevents Brain Damage in Mice

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MMJ Ingre­di­ent Pre­vents Brain Dam­age in Mice

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