A Double Blind, Active Placebo Controlled Crossover Trial of the Antinociceptive Effects of Smoked Marijuana on Subjects with Neuropathic Pain; Correlation with Changes in Mood, Cognition, and Psychomotor Performance

May 18, 2011

Thirty-eight patients with cen­tral and periph­eral neu­ro­pathic pain under­went a stan­dard­ized pro­ce­dure for smok­ing either high-dose (7%), low-dose (3.5%) or placebo cannabis. In addi­tion to the pri­mary out­come of pain inten­sity, sec­ondary out­come mea­sures included evoked pain using heat-pain thresh­old, sen­si­tiv­ity to light touch, psy­choac­tive side-effects, and neu­ropsy­cho­log­i­cal per­for­mance. A mixed lin­ear model demon­strated an anal­gesic response to smok­ing cannabis. No effect on evoked pain was seen. Psy­choac­tive effects were min­i­mal and well-tolerated, with some acute cog­ni­tive effects, par­tic­u­larly with mem­ory, at higher doses.
The full results of this study have been pub­lished in the Jour­nal of Pain.


And yes… there is a Jour­nal of Pain.

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